Molecular Biology of Human Cancers: An Advanced Student's Textbook
Publisher: Springer | ISBN: 1402031858 | edition 2005 | PDF | 530 pages | 14,6 mb
Publisher: Springer | ISBN: 1402031858 | edition 2005 | PDF | 530 pages | 14,6 mb
Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and, prominently, into inherited susceptibility to cancer. Accordingly, Part I of the book presents many of the important molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion and metastasis.
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